ARHGEF11-SMCP Fusion FISH Probe
The ARHGEF11-SMCP Fusion FISH Probe is used to confirm a fusion of the ARHGEF11 and SMCP genes. The fusion of the ARHGEF11 and SMCP genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARHGEF11-SMCP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-RERE | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-REOR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-REGO | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-REGR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-REAQ | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-ORRE | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-OROR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-ORGO | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-GORE | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-GOOR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-GOGO | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-GOGR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-GRRE | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-GROR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-GRGO | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-GRGR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-AQRE | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-AQOR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-AQGO | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-AQGR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SMCP-20-AQAQ | 20 (40 μL) | 200 μL |
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SMCP Gene Summary
Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008]
Gene Name: Sperm Mitochondria Associated Cysteine Rich Protein
Chromosome: CHR1: 152850797 -152857523
Locus: 1q21.3
ARHGEF11 Gene Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Rho Guanine Nucleotide Exchange Factor 11
Chromosome: CHR1: 156904631 -157015162
Locus: 1q23.1
Gene Diseases
The ARHGEF11 SMCP Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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