ARHGEF18-MYO9B Fusion FISH Probe
The ARHGEF18-MYO9B Fusion FISH Probe is used to confirm a fusion of the ARHGEF18 and MYO9B genes. The fusion of the ARHGEF18 and MYO9B genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARHGEF18-MYO9B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-RERE | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-REOR | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-REGO | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-REGR | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-REAQ | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-ORRE | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-OROR | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-ORGO | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-GORE | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-GOOR | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-GOGO | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-GOGR | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-GRRE | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-GROR | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-GRGO | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-GRGR | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-AQRE | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-AQOR | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-AQGO | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-AQGR | 20 (40 μL) | 200 μL |
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| ARHGEF18-MYO9B-20-AQAQ | 20 (40 μL) | 200 μL |
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MYO9B Gene Summary
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Myosin IXB
Chromosome: CHR19: 17186590 -17324104
Locus: 19p13.11
ARHGEF18 Gene Summary
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Gene Name: Rho/Rac Guanine Nucleotide Exchange Factor 18
Chromosome: CHR19: 7459998 -7537371
Locus: 19p13.2
Gene Diseases
The ARHGEF18 MYO9B Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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