ARHGEF3-ARF4 Fusion FISH Probe
The ARHGEF3-ARF4 Fusion FISH Probe is used to confirm a fusion of the ARHGEF3 and ARF4 genes. The fusion of the ARHGEF3 and ARF4 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARHGEF3-ARF4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-RERE | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-REOR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-REGO | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-REGR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-REAQ | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-ORRE | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-OROR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-ORGO | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-GORE | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-GOOR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-GOGO | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-GOGR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-GRRE | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-GROR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-GRGO | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-GRGR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-AQRE | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-AQOR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-AQGO | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-AQGR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ARF4-20-AQAQ | 20 (40 μL) | 200 μL |
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ARF4 Gene Summary
This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor 4
Chromosome: CHR3: 57557089 -57583215
Locus: 3p14.3
ARHGEF3 Gene Summary
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Rho Guanine Nucleotide Exchange Factor 3
Chromosome: CHR3: 56761445 -57113336
Locus: 3p14.3
Gene Diseases
The ARHGEF3 ARF4 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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