ARHGEF3-LTF Fusion FISH Probe
The ARHGEF3-LTF Fusion FISH Probe is used to confirm a fusion of the ARHGEF3 and LTF genes. The fusion of the ARHGEF3 and LTF genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARHGEF3-LTF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-RERE | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-REOR | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-REGO | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-REGR | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-REAQ | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-ORRE | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-OROR | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-ORGO | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-GORE | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-GOOR | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-GOGO | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-GOGR | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-GRRE | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-GROR | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-GRGO | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-GRGR | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-AQRE | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-AQOR | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-AQGO | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-AQGR | 20 (40 μL) | 200 μL |
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| ARHGEF3-LTF-20-AQAQ | 20 (40 μL) | 200 μL |
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LTF Gene Summary
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Gene Name: Lactotransferrin
Chromosome: CHR3: 46477495 -46506598
Locus: 3p21.31
ARHGEF3 Gene Summary
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Rho Guanine Nucleotide Exchange Factor 3
Chromosome: CHR3: 56761445 -57113336
Locus: 3p14.3
Gene Diseases
The ARHGEF3 LTF Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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