ARHGEF7-PTEN Fusion FISH Probe
The ARHGEF7-PTEN Fusion FISH Probe is used to confirm a fusion of the ARHGEF7 and PTEN genes. The fusion of the ARHGEF7 and PTEN genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARHGEF7-PTEN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-RERE | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-REOR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-REGO | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-REGR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-REAQ | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-ORRE | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-OROR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-ORGO | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GORE | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GOOR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GOGO | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GOGR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GRRE | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GROR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GRGO | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GRGR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-AQRE | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-AQOR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-AQGO | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-AQGR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-AQAQ | 20 (40 μL) | 200 μL |
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PTEN Gene Summary
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Gene Name: Phosphatase And Tensin Homolog
Chromosome: CHR10: 89623194 -89728532
Locus: 10q23.31
ARHGEF7 Gene Summary
This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]
Gene Name: Rho Guanine Nucleotide Exchange Factor 7
Chromosome: CHR13: 111767623 -111947542
Locus: 13q34
Gene Diseases
The ARHGEF7 PTEN Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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