ARID1A-PRKCZ Fusion FISH Probe
The ARID1A-PRKCZ Fusion FISH Probe is used to confirm a fusion of the ARID1A and PRKCZ genes. The fusion of the ARID1A and PRKCZ genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARID1A-PRKCZ-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-RERE | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-REOR | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-REGO | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-REGR | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-REAQ | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-ORRE | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-OROR | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-ORGO | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-GORE | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-GOOR | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-GOGO | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-GOGR | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-GRRE | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-GROR | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-GRGO | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-GRGR | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-AQRE | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-AQOR | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-AQGO | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-AQGR | 20 (40 μL) | 200 μL |
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| ARID1A-PRKCZ-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKCZ Gene Summary
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase C Zeta
Chromosome: CHR1: 1981908 -2116834
Locus: 1p36.33
ARID1A Gene Summary
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: AT-rich Interaction Domain 1A
Chromosome: CHR1: 27022521 -27108601
Locus: 1p36.11
Gene Diseases
The ARID1A PRKCZ Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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