ARID1B-SASH1 Fusion FISH Probe
The ARID1B-SASH1 Fusion FISH Probe is used to confirm a fusion of the ARID1B and SASH1 genes. The fusion of the ARID1B and SASH1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARID1B-SASH1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-RERE | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-REOR | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-REGO | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-REGR | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-REAQ | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-ORRE | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-OROR | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-ORGO | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-GORE | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-GOOR | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-GOGO | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-GOGR | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-GRRE | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-GROR | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-GRGO | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-GRGR | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-AQRE | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-AQOR | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-AQGO | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-AQGR | 20 (40 μL) | 200 μL |
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| ARID1B-SASH1-20-AQAQ | 20 (40 μL) | 200 μL |
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SASH1 Gene Summary
This gene encodes a scaffold protein involved in the TLR4 signaling pathway that may stimulate cytokine production and endothelial cell migration in response to invading pathogens. The encoded protein has also been described as a potential tumor suppressor that may negatively regulate proliferation, apoptosis, and invasion of cancer cells, and reduced expression of this gene has been observed in multiple human cancers. Mutations in this gene may be associated with abnormal skin pigmentation in human patients. [provided by RefSeq, Oct 2016]
Gene Name: SAM And SH3 Domain Containing 1
Chromosome: CHR6: 148663728 -148873184
Locus: 6q24.3-q25.1
ARID1B Gene Summary
This locus encodes an AT-rich DNA interacting domain-containing protein. The encoded protein is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation. The protein encoded by this locus is similar to AT-rich interactive domain-containing protein 1A. These two proteins function as alternative, mutually exclusive ARID-subunits of the SWI/SNF complex. The associated complexes play opposing roles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Gene Name: AT-rich Interaction Domain 1B
Chromosome: CHR6: 157099063 -157531913
Locus: 6q25.3
Gene Diseases
The ARID1B SASH1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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