ARID2-SPSB2 Fusion FISH Probe
The ARID2-SPSB2 Fusion FISH Probe is used to confirm a fusion of the ARID2 and SPSB2 genes. The fusion of the ARID2 and SPSB2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARID2-SPSB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-RERE | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-REOR | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-REGO | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-REGR | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-REAQ | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-ORRE | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-OROR | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-ORGO | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-GORE | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-GOOR | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-GOGO | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-GOGR | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-GRRE | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-GROR | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-GRGO | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-GRGR | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-AQRE | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-AQOR | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-AQGO | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-AQGR | 20 (40 μL) | 200 μL |
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| ARID2-SPSB2-20-AQAQ | 20 (40 μL) | 200 μL |
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SPSB2 Gene Summary
This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Name: SplA/ryanodine Receptor Domain And SOCS Box Containing 2
Chromosome: CHR12: 6980099 -6982521
Locus: 12p13.31
ARID2 Gene Summary
This gene encodes a member of the AT-rich interactive domain (ARID)-containing family of DNA-binding proteins. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and chromatin structure modification. This protein functions as a subunit of the polybromo- and BRG1-associated factor or PBAF (SWI/SNF-B) chromatin remodeling complex which facilitates ligand-dependent transcriptional activation by nuclear receptors. Mutations in this gene are associated with hepatocellular carcinomas. A pseudogene of this gene is found on chromosome1. [provided by RefSeq, Dec 2016]
Gene Name: AT-rich Interaction Domain 2
Chromosome: CHR12: 46123619 -46301819
Locus: 12q12
Gene Diseases
The ARID2 SPSB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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