ARID4B-KLHL12 Fusion FISH Probe
The ARID4B-KLHL12 Fusion FISH Probe is used to confirm a fusion of the ARID4B and KLHL12 genes. The fusion of the ARID4B and KLHL12 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ARID4B-KLHL12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-RERE | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-REOR | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-REGO | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-REGR | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-OROR | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-GORE | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-GROR | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| ARID4B-KLHL12-20-AQAQ | 20 (40 μL) | 200 μL |
|
ARID4B Gene Summary
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: AT-rich Interaction Domain 4B
Chromosome: CHR1: 235330209 -235491532
Locus: 1q42.3
KLHL12 Gene Summary
This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Kelch Like Family Member 12
Chromosome: CHR1: 202860229 -202896371
Locus: 1q32.1
Gene Diseases
The ARID4B KLHL12 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|