ARL1-UBE2N Fusion FISH Probe
The ARL1-UBE2N Fusion FISH Probe is used to confirm a fusion of the ARL1 and UBE2N genes. The fusion of the ARL1 and UBE2N genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARL1-UBE2N-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-RERE | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-REOR | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-REGO | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-REGR | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-REAQ | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-ORRE | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-OROR | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-ORGO | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-GORE | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-GOOR | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-GOGO | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-GOGR | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-GRRE | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-GROR | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-GRGO | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-GRGR | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-AQRE | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-AQOR | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-AQGO | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-AQGR | 20 (40 μL) | 200 μL |
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| ARL1-UBE2N-20-AQAQ | 20 (40 μL) | 200 μL |
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ARL1 Gene Summary
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Gene Name: ADP Ribosylation Factor Like GTPase 1
Chromosome: CHR12: 101786902 -101801572
Locus: 12q23.2
UBE2N Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Conjugating Enzyme E2 N
Chromosome: CHR12: 93802087 -93836026
Locus: 12q22
Gene Diseases
The ARL1 UBE2N Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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