ARMC8-CACNA2D2 Fusion FISH Probe
The ARMC8-CACNA2D2 Fusion FISH Probe is used to confirm a fusion of the ARMC8 and CACNA2D2 genes. The fusion of the ARMC8 and CACNA2D2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARMC8-CACNA2D2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-RERE | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-REOR | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-REGO | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-REGR | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-REAQ | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-ORRE | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-OROR | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-ORGO | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-GORE | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-GOOR | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-GOGO | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-GOGR | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-GRRE | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-GROR | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-GRGO | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-GRGR | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-AQRE | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-AQOR | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-AQGO | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-AQGR | 20 (40 μL) | 200 μL |
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| ARMC8-CACNA2D2-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNA2D2 Gene Summary
Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Gene Name: Calcium Voltage-gated Channel Auxiliary Subunit Alpha2delta 2
Chromosome: CHR3: 50400230 -50540892
Locus: 3p21.31
ARMC8 Gene Summary
The Armadillo Repeat Containing 8 (ARMC8) gene is located on chr3 :137906147-138016219 at 3q22.3.
Gene Name: Armadillo Repeat Containing 8
Chromosome: CHR3: 137906147 -138016219
Locus: 3q22.3
Gene Diseases
The ARMC8 CACNA2D2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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