ARMC8-CLDN18 Fusion FISH Probe
The ARMC8-CLDN18 Fusion FISH Probe is used to confirm a fusion of the ARMC8 and CLDN18 genes. The fusion of the ARMC8 and CLDN18 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARMC8-CLDN18-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-RERE | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-REOR | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-REGO | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-REGR | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-REAQ | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-ORRE | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-OROR | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-ORGO | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-GORE | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-GOOR | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-GOGO | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-GOGR | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-GRRE | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-GROR | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-GRGO | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-GRGR | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-AQRE | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-AQOR | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-AQGO | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-AQGR | 20 (40 μL) | 200 μL |
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| ARMC8-CLDN18-20-AQAQ | 20 (40 μL) | 200 μL |
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ARMC8 Gene Summary
The Armadillo Repeat Containing 8 (ARMC8) gene is located on chr3 :137906147-138016219 at 3q22.3.
Gene Name: Armadillo Repeat Containing 8
Chromosome: CHR3: 137906147 -138016219
Locus: 3q22.3
CLDN18 Gene Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
Gene Name: Claudin 18
Chromosome: CHR3: 137717657 -137752494
Locus: 3q22.3
Gene Diseases
The ARMC8 CLDN18 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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