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ARNTL-TEAD1 Fusion FISH Probe

The ARNTL-TEAD1 Fusion FISH Probe is used to confirm a fusion of the ARNTL and TEAD1 genes. The fusion of the ARNTL and TEAD1 genes has been associated with Breast Invasive Carcinoma, and Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ARNTL-TEAD1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ARNTL-TEAD1-20-RERE 20 (40 μL) 200 μL
ARNTL-TEAD1-20-REOR 20 (40 μL) 200 μL
ARNTL-TEAD1-20-REGO 20 (40 μL) 200 μL
ARNTL-TEAD1-20-REGR 20 (40 μL) 200 μL
ARNTL-TEAD1-20-REAQ 20 (40 μL) 200 μL
ARNTL-TEAD1-20-ORRE 20 (40 μL) 200 μL
ARNTL-TEAD1-20-OROR 20 (40 μL) 200 μL
ARNTL-TEAD1-20-ORGO 20 (40 μL) 200 μL
ARNTL-TEAD1-20-ORAQ 20 (40 μL) 200 μL
ARNTL-TEAD1-20-GORE 20 (40 μL) 200 μL
ARNTL-TEAD1-20-GOOR 20 (40 μL) 200 μL
ARNTL-TEAD1-20-GOGO 20 (40 μL) 200 μL
ARNTL-TEAD1-20-GOGR 20 (40 μL) 200 μL
ARNTL-TEAD1-20-GOAQ 20 (40 μL) 200 μL
ARNTL-TEAD1-20-GRRE 20 (40 μL) 200 μL
ARNTL-TEAD1-20-GROR 20 (40 μL) 200 μL
ARNTL-TEAD1-20-GRGO 20 (40 μL) 200 μL
ARNTL-TEAD1-20-GRGR 20 (40 μL) 200 μL
ARNTL-TEAD1-20-GRAQ 20 (40 μL) 200 μL
ARNTL-TEAD1-20-AQRE 20 (40 μL) 200 μL
ARNTL-TEAD1-20-AQOR 20 (40 μL) 200 μL
ARNTL-TEAD1-20-AQGO 20 (40 μL) 200 μL
ARNTL-TEAD1-20-AQGR 20 (40 μL) 200 μL
ARNTL-TEAD1-20-AQAQ 20 (40 μL) 200 μL

ARNTL Gene Summary

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Gene Name: Aryl Hydrocarbon Receptor Nuclear Translocator Like

Chromosome: CHR11: 13299324 -13408812

Locus: 11p15.3

TEAD1 Gene Summary

This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]

Gene Name: TEA Domain Transcription Factor 1

Chromosome: CHR11: 12695968 -12966284

Locus: 11p15.3

Gene Diseases

The ARNTL TEAD1 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma
Head And Neck Squamous Cell Carcinoma 

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.