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ARRB1-PRCP Fusion FISH Probe

The ARRB1-PRCP Fusion FISH Probe is used to confirm a fusion of the ARRB1 and PRCP genes. The fusion of the ARRB1 and PRCP genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ARRB1-PRCP-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ARRB1-PRCP-20-RERE 20 (40 μL) 200 μL
ARRB1-PRCP-20-REOR 20 (40 μL) 200 μL
ARRB1-PRCP-20-REGO 20 (40 μL) 200 μL
ARRB1-PRCP-20-REGR 20 (40 μL) 200 μL
ARRB1-PRCP-20-REAQ 20 (40 μL) 200 μL
ARRB1-PRCP-20-ORRE 20 (40 μL) 200 μL
ARRB1-PRCP-20-OROR 20 (40 μL) 200 μL
ARRB1-PRCP-20-ORGO 20 (40 μL) 200 μL
ARRB1-PRCP-20-ORAQ 20 (40 μL) 200 μL
ARRB1-PRCP-20-GORE 20 (40 μL) 200 μL
ARRB1-PRCP-20-GOOR 20 (40 μL) 200 μL
ARRB1-PRCP-20-GOGO 20 (40 μL) 200 μL
ARRB1-PRCP-20-GOGR 20 (40 μL) 200 μL
ARRB1-PRCP-20-GOAQ 20 (40 μL) 200 μL
ARRB1-PRCP-20-GRRE 20 (40 μL) 200 μL
ARRB1-PRCP-20-GROR 20 (40 μL) 200 μL
ARRB1-PRCP-20-GRGO 20 (40 μL) 200 μL
ARRB1-PRCP-20-GRGR 20 (40 μL) 200 μL
ARRB1-PRCP-20-GRAQ 20 (40 μL) 200 μL
ARRB1-PRCP-20-AQRE 20 (40 μL) 200 μL
ARRB1-PRCP-20-AQOR 20 (40 μL) 200 μL
ARRB1-PRCP-20-AQGO 20 (40 μL) 200 μL
ARRB1-PRCP-20-AQGR 20 (40 μL) 200 μL
ARRB1-PRCP-20-AQAQ 20 (40 μL) 200 μL

ARRB1 Gene Summary

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

Gene Name: Arrestin Beta 1

Chromosome: CHR11: 74971165 -75062875

Locus: 11q13.4

PRCP Gene Summary

This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Gene Name: Prolylcarboxypeptidase

Chromosome: CHR11: 82535408 -82611557

Locus: 11q14.1

Gene Diseases

The ARRB1 PRCP Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.