ASAH1-DDX21 Fusion FISH Probe
The ASAH1-DDX21 Fusion FISH Probe is used to confirm a fusion of the ASAH1 and DDX21 genes. The fusion of the ASAH1 and DDX21 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ASAH1-DDX21-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-RERE | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-REOR | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-REGO | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-REGR | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-REAQ | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-ORRE | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-OROR | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-ORGO | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-ORAQ | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-GORE | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-GOOR | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-GOGO | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-GOGR | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-GOAQ | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-GRRE | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-GROR | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-GRGO | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-GRGR | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-GRAQ | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-AQRE | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-AQOR | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-AQGO | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-AQGR | 20 (40 μL) | 200 μL |
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| ASAH1-DDX21-20-AQAQ | 20 (40 μL) | 200 μL |
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ASAH1 Gene Summary
This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. [provided by RefSeq, Oct 2015]
Gene Name: N-acylsphingosine Amidohydrolase 1
Chromosome: CHR8: 17913924 -17942507
Locus: 8p22
DDX21 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
Gene Name: DExD-box Helicase 21
Chromosome: CHR10: 70715891 -70744279
Locus: 10q22.1
Gene Diseases
The ASAH1 DDX21 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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