ASPH-CHMP1A Fusion FISH Probe
The ASPH-CHMP1A Fusion FISH Probe is used to confirm a fusion of the ASPH and CHMP1A genes. The fusion of the ASPH and CHMP1A genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ASPH-CHMP1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-RERE | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-REOR | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-REGO | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-REGR | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-REAQ | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-ORRE | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-OROR | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-ORGO | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-GORE | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-GOOR | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-GOGO | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-GOGR | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-GRRE | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-GROR | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-GRGO | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-GRGR | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-AQRE | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-AQOR | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-AQGO | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-AQGR | 20 (40 μL) | 200 μL |
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| ASPH-CHMP1A-20-AQAQ | 20 (40 μL) | 200 μL |
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ASPH Gene Summary
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]
Gene Name: Aspartate Beta-hydroxylase
Chromosome: CHR8: 62413114 -62627199
Locus: 8q12.3
CHMP1A Gene Summary
This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Name: Charged Multivesicular Body Protein 1A
Chromosome: CHR16: 89710843 -89724129
Locus: 16q24.3
Gene Diseases
The ASPH CHMP1A Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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