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ATAD2-ERBB4 Fusion FISH Probe

The ATAD2-ERBB4 Fusion FISH Probe is used to confirm a fusion of the ATAD2 and ERBB4 genes. The fusion of the ATAD2 and ERBB4 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ATAD2-ERBB4-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ATAD2-ERBB4-20-RERE 20 (40 μL) 200 μL
ATAD2-ERBB4-20-REOR 20 (40 μL) 200 μL
ATAD2-ERBB4-20-REGO 20 (40 μL) 200 μL
ATAD2-ERBB4-20-REGR 20 (40 μL) 200 μL
ATAD2-ERBB4-20-REAQ 20 (40 μL) 200 μL
ATAD2-ERBB4-20-ORRE 20 (40 μL) 200 μL
ATAD2-ERBB4-20-OROR 20 (40 μL) 200 μL
ATAD2-ERBB4-20-ORGO 20 (40 μL) 200 μL
ATAD2-ERBB4-20-ORAQ 20 (40 μL) 200 μL
ATAD2-ERBB4-20-GORE 20 (40 μL) 200 μL
ATAD2-ERBB4-20-GOOR 20 (40 μL) 200 μL
ATAD2-ERBB4-20-GOGO 20 (40 μL) 200 μL
ATAD2-ERBB4-20-GOGR 20 (40 μL) 200 μL
ATAD2-ERBB4-20-GOAQ 20 (40 μL) 200 μL
ATAD2-ERBB4-20-GRRE 20 (40 μL) 200 μL
ATAD2-ERBB4-20-GROR 20 (40 μL) 200 μL
ATAD2-ERBB4-20-GRGO 20 (40 μL) 200 μL
ATAD2-ERBB4-20-GRGR 20 (40 μL) 200 μL
ATAD2-ERBB4-20-GRAQ 20 (40 μL) 200 μL
ATAD2-ERBB4-20-AQRE 20 (40 μL) 200 μL
ATAD2-ERBB4-20-AQOR 20 (40 μL) 200 μL
ATAD2-ERBB4-20-AQGO 20 (40 μL) 200 μL
ATAD2-ERBB4-20-AQGR 20 (40 μL) 200 μL
ATAD2-ERBB4-20-AQAQ 20 (40 μL) 200 μL

ERBB4 Gene Summary

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Gene Name: Erb-b2 Receptor Tyrosine Kinase 4

Chromosome: CHR2: 212240441 -213403352

Locus: 2q34

ATAD2 Gene Summary

A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]

Gene Name: ATPase Family, AAA Domain Containing 2

Chromosome: CHR8: 124332090 -124408705

Locus: 8q24.13

Gene Diseases

The ATAD2 ERBB4 Fusion has been associated with the following diseases:

Disease Name
Head And Neck Squamous Cell Carcinoma 

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Next-Generation Sequencing to Detect Deletion of RB1 and ERBB4 Genes in Chromophobe Renal Cell Carcinoma: A Potential Role in Distinguishing Chromophobe Renal Cell Carcinoma from Renal Oncocytoma

Chromophobe renal cell carcinoma (ChRCC) and renal oncocytoma (RO) are two tumors that are difficult to distinguish from one another. It is important to distinguish them because ChRCC is a malignant tumor whereas RO is a benign tumor. Deletion of the RB1 and ERBB4 genes are indicative of ChRCC because these are tumor-suppressant genes. FISH analysis was used to identify these deletions. Our dual color probes were used that targeted RB1-Orange (MAC clone RP11-893E5) and 13q11-Green (RP11-408E5). A green ERBB4 probe was also used.

The Utility of ERBB4 and RB1 Immunohistochemistry in Distinguishing Chromophobe Renal Cell Carcinoma From Renal Oncocytoma

Renal oncocytoma (RO) is a benign epithelial neoplasm that makes up about 5 to 9% of all renal cell tumors. RO can be difficult to distinguish from a closely related but malignant counterpart, chromophobe renal cell carcinoma (ChrCC). This study used both IHC and FISH to detect the presence of RB1 and ERBB4, two genes that have been found deleted in ChrCC but not RO. A total of 28 ChrCCs and 25 RO cases were tested. Empire Genomics’ RB1 and ERBB4 FISH probes were used to detect deletions in these genes.