ATG5-EPHA7 Fusion FISH Probe
The ATG5-EPHA7 Fusion FISH Probe is used to confirm a fusion of the ATG5 and EPHA7 genes. The fusion of the ATG5 and EPHA7 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATG5-EPHA7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-RERE | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-REOR | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-REGO | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-REGR | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-REAQ | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-ORRE | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-OROR | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-ORGO | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-GORE | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-GOOR | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-GOGO | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-GOGR | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-GRRE | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-GROR | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-GRGO | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-GRGR | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-AQRE | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-AQOR | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-AQGO | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-AQGR | 20 (40 μL) | 200 μL |
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| ATG5-EPHA7-20-AQAQ | 20 (40 μL) | 200 μL |
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EPHA7 Gene Summary
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Name: EPH Receptor A7
Chromosome: CHR6: 93949739 -94129300
Locus: 6q16.1
ATG5 Gene Summary
The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Gene Name: Autophagy Related 5
Chromosome: CHR6: 106632351 -106773695
Locus: 6q21
Gene Diseases
The ATG5 EPHA7 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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