ATG7-BRAF Fusion FISH Probe
The ATG7-BRAF Fusion FISH Probe is used to confirm a fusion of the ATG7 and BRAF genes. The fusion of the ATG7 and BRAF genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATG7-BRAF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-RERE | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-REOR | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-REGO | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-REGR | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-REAQ | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-ORRE | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-OROR | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-ORGO | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-GORE | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-GOOR | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-GOGO | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-GOGR | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-GRRE | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-GROR | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-GRGO | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-GRGR | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-AQRE | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-AQOR | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-AQGO | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-AQGR | 20 (40 μL) | 200 μL |
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| ATG7-BRAF-20-AQAQ | 20 (40 μL) | 200 μL |
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BRAF Gene Summary
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Gene Name: B-Raf Proto-oncogene, Serine/threonine Kinase
Chromosome: CHR7: 140433812 -140624564
Locus: 7q34
ATG7 Gene Summary
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Gene Name: Autophagy Related 7
Chromosome: CHR3: 11314009 -11599139
Locus: 3p25.3
Gene Diseases
The ATG7 BRAF Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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