ATL3-RTN3 Fusion FISH Probe
The ATL3-RTN3 Fusion FISH Probe is used to confirm a fusion of the ATL3 and RTN3 genes. The fusion of the ATL3 and RTN3 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATL3-RTN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-RERE | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-REOR | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-REGO | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-REGR | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-REAQ | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-ORRE | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-OROR | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-ORGO | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-GORE | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-GOOR | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-GOGO | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-GOGR | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-GRRE | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-GROR | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-GRGO | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-GRGR | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-AQRE | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-AQOR | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-AQGO | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-AQGR | 20 (40 μL) | 200 μL |
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| ATL3-RTN3-20-AQAQ | 20 (40 μL) | 200 μL |
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RTN3 Gene Summary
This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]
Gene Name: Reticulon 3
Chromosome: CHR11: 63448921 -63527363
Locus: 11q13.1
ATL3 Gene Summary
This gene encodes a member of a family of dynamin-like, integral membrane GTPases. The encoded protein is required for the proper formation of the network of interconnected tubules of the endoplasmic reticulum. Mutations in this gene may be associated with hereditary sensory neuropathy type IF. Alternatively spliced transcript variants that encode distinct isoforms have been described. [provided by RefSeq, Feb 2014]
Gene Name: Atlastin GTPase 3
Chromosome: CHR11: 63396436 -63439083
Locus: 11q13.1
Gene Diseases
The ATL3 RTN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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