ATP1A1-NOTCH2 Fusion FISH Probe
The ATP1A1-NOTCH2 Fusion FISH Probe is used to confirm a fusion of the ATP1A1 and NOTCH2 genes. The fusion of the ATP1A1 and NOTCH2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATP1A1-NOTCH2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-RERE | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-REOR | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-REGO | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-REGR | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-REAQ | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-ORRE | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-OROR | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-ORGO | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-GORE | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-GOOR | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-GOGO | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-GOGR | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-GRRE | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-GROR | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-GRGO | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-GRGR | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-AQRE | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-AQOR | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-AQGO | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-AQGR | 20 (40 μL) | 200 μL |
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| ATP1A1-NOTCH2-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP1A1 Gene Summary
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Name: ATPase Na+/K+ Transporting Subunit Alpha 1
Chromosome: CHR1: 116915794 -116947396
Locus: 1p13.1
NOTCH2 Gene Summary
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Name: Notch 2
Chromosome: CHR1: 120454175 -120612317
Locus: 1p12
Gene Diseases
The ATP1A1 NOTCH2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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