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ATRX-ZNF304 Fusion FISH Probe

The ATRX-ZNF304 Fusion FISH Probe is used to confirm a fusion of the ATRX and ZNF304 genes. The fusion of the ATRX and ZNF304 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ATRX-ZNF304-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ATRX-ZNF304-20-RERE 20 (40 μL) 200 μL
ATRX-ZNF304-20-REOR 20 (40 μL) 200 μL
ATRX-ZNF304-20-REGO 20 (40 μL) 200 μL
ATRX-ZNF304-20-REGR 20 (40 μL) 200 μL
ATRX-ZNF304-20-REAQ 20 (40 μL) 200 μL
ATRX-ZNF304-20-ORRE 20 (40 μL) 200 μL
ATRX-ZNF304-20-OROR 20 (40 μL) 200 μL
ATRX-ZNF304-20-ORGO 20 (40 μL) 200 μL
ATRX-ZNF304-20-ORAQ 20 (40 μL) 200 μL
ATRX-ZNF304-20-GORE 20 (40 μL) 200 μL
ATRX-ZNF304-20-GOOR 20 (40 μL) 200 μL
ATRX-ZNF304-20-GOGO 20 (40 μL) 200 μL
ATRX-ZNF304-20-GOGR 20 (40 μL) 200 μL
ATRX-ZNF304-20-GOAQ 20 (40 μL) 200 μL
ATRX-ZNF304-20-GRRE 20 (40 μL) 200 μL
ATRX-ZNF304-20-GROR 20 (40 μL) 200 μL
ATRX-ZNF304-20-GRGO 20 (40 μL) 200 μL
ATRX-ZNF304-20-GRGR 20 (40 μL) 200 μL
ATRX-ZNF304-20-GRAQ 20 (40 μL) 200 μL
ATRX-ZNF304-20-AQRE 20 (40 μL) 200 μL
ATRX-ZNF304-20-AQOR 20 (40 μL) 200 μL
ATRX-ZNF304-20-AQGO 20 (40 μL) 200 μL
ATRX-ZNF304-20-AQGR 20 (40 μL) 200 μL
ATRX-ZNF304-20-AQAQ 20 (40 μL) 200 μL

ATRX Gene Summary

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]

Gene Name: ATRX, Chromatin Remodeler

Chromosome: CHRX: 76760355 -77041719

Locus: Xq21.1

ZNF304 Gene Summary

This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein functions as a transcriptional repressor that recruits a corepressor complex to stimulate promoter hypermethylation and transcriptional silencing of target genes. Expression of this gene is upregulated in colorectal, ovarian and breast cancer, and this gene may promote cancer cell survival, growth and invasion. [provided by RefSeq, Jul 2016]

Gene Name: Zinc Finger Protein 304

Chromosome: CHR19: 57862644 -57871265

Locus: 19q13.43

Gene Diseases

The ATRX ZNF304 Fusion has been associated with the following diseases:

Disease Name
Brain Lower Grade Glioma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.