AXIN2-EIF2AK2 Fusion FISH Probe
The AXIN2-EIF2AK2 Fusion FISH Probe is used to confirm a fusion of the AXIN2 and EIF2AK2 genes. The fusion of the AXIN2 and EIF2AK2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AXIN2-EIF2AK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-RERE | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-REOR | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-REGO | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-REGR | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-REAQ | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-ORRE | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-OROR | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-ORGO | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-GORE | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-GOOR | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-GOGO | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-GOGR | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-GRRE | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-GROR | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-GRGO | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-GRGR | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-AQRE | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-AQOR | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-AQGO | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-AQGR | 20 (40 μL) | 200 μL |
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| AXIN2-EIF2AK2-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF2AK2 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Chromosome: CHR2: 37333698 -37384190
Locus: 2p22.2
AXIN2 Gene Summary
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
Gene Name: Axin 2
Chromosome: CHR17: 63524682 -63557740
Locus: 17q24.1
Gene Diseases
The AXIN2 EIF2AK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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