AXIN2-VWA3B Fusion FISH Probe
The AXIN2-VWA3B Fusion FISH Probe is used to confirm a fusion of the AXIN2 and VWA3B genes. The fusion of the AXIN2 and VWA3B genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AXIN2-VWA3B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-RERE | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-REOR | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-REGO | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-REGR | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-REAQ | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-ORRE | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-OROR | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-ORGO | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-ORAQ | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-GORE | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-GOOR | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-GOGO | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-GOGR | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-GOAQ | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-GRRE | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-GROR | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-GRGO | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-GRGR | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-GRAQ | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-AQRE | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-AQOR | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-AQGO | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-AQGR | 20 (40 μL) | 200 μL |
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| AXIN2-VWA3B-20-AQAQ | 20 (40 μL) | 200 μL |
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AXIN2 Gene Summary
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
Gene Name: Axin 2
Chromosome: CHR17: 63524682 -63557740
Locus: 17q24.1
VWA3B Gene Summary
This gene encodes an intracellular protein that contains a von Willebrand factor type A domain. Intracellular proteins with VWA domains are thought to function in transcription, DNA repair, ribosomal and membrane transport and the proteasome. Mutations in this gene are associated with Spinocerebellar ataxia, autosomal recessive 22. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2017]
Gene Name: Von Willebrand Factor A Domain Containing 3B
Chromosome: CHR2: 98703594 -98929410
Locus: 2q11.2
Gene Diseases
The AXIN2 VWA3B Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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