AZIN1-ATP6V1C1 Fusion FISH Probe
The AZIN1-ATP6V1C1 Fusion FISH Probe is used to confirm a fusion of the AZIN1 and ATP6V1C1 genes. The fusion of the AZIN1 and ATP6V1C1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AZIN1-ATP6V1C1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-RERE | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-REOR | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-REGO | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-REGR | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-REAQ | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-ORRE | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-OROR | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-ORGO | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-ORAQ | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-GORE | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-GOOR | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-GOGO | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-GOGR | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-GOAQ | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-GRRE | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-GROR | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-GRGO | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-GRGR | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-GRAQ | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-AQRE | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-AQOR | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-AQGO | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-AQGR | 20 (40 μL) | 200 μL |
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| AZIN1-ATP6V1C1-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP6V1C1 Gene Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq, Jul 2008]
Gene Name: ATPase H+ Transporting V1 Subunit C1
Chromosome: CHR8: 104033247 -104085285
Locus: 8q22.3
AZIN1 Gene Summary
The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
Gene Name: Antizyme Inhibitor 1
Chromosome: CHR8: 103838535 -103876397
Locus: 8q22.3
Gene Diseases
The AZIN1 ATP6V1C1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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