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B4GALT1-AQP7 Fusion FISH Probe

The B4GALT1-AQP7 Fusion FISH Probe is used to confirm a fusion of the B4GALT1 and AQP7 genes. The fusion of the B4GALT1 and AQP7 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
B4GALT1-AQP7-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
B4GALT1-AQP7-20-RERE 20 (40 μL) 200 μL
B4GALT1-AQP7-20-REOR 20 (40 μL) 200 μL
B4GALT1-AQP7-20-REGO 20 (40 μL) 200 μL
B4GALT1-AQP7-20-REGR 20 (40 μL) 200 μL
B4GALT1-AQP7-20-REAQ 20 (40 μL) 200 μL
B4GALT1-AQP7-20-ORRE 20 (40 μL) 200 μL
B4GALT1-AQP7-20-OROR 20 (40 μL) 200 μL
B4GALT1-AQP7-20-ORGO 20 (40 μL) 200 μL
B4GALT1-AQP7-20-ORAQ 20 (40 μL) 200 μL
B4GALT1-AQP7-20-GORE 20 (40 μL) 200 μL
B4GALT1-AQP7-20-GOOR 20 (40 μL) 200 μL
B4GALT1-AQP7-20-GOGO 20 (40 μL) 200 μL
B4GALT1-AQP7-20-GOGR 20 (40 μL) 200 μL
B4GALT1-AQP7-20-GOAQ 20 (40 μL) 200 μL
B4GALT1-AQP7-20-GRRE 20 (40 μL) 200 μL
B4GALT1-AQP7-20-GROR 20 (40 μL) 200 μL
B4GALT1-AQP7-20-GRGO 20 (40 μL) 200 μL
B4GALT1-AQP7-20-GRGR 20 (40 μL) 200 μL
B4GALT1-AQP7-20-GRAQ 20 (40 μL) 200 μL
B4GALT1-AQP7-20-AQRE 20 (40 μL) 200 μL
B4GALT1-AQP7-20-AQOR 20 (40 μL) 200 μL
B4GALT1-AQP7-20-AQGO 20 (40 μL) 200 μL
B4GALT1-AQP7-20-AQGR 20 (40 μL) 200 μL
B4GALT1-AQP7-20-AQAQ 20 (40 μL) 200 μL

AQP7 Gene Summary

This gene encodes a member of the aquaporin family of water-selective membrane channels. The encoded protein localizes to the plasma membrane and allows movement of water, glycerol and urea across cell membranes. This gene is highly expressed in the adipose tissue where the encoded protein facilitates efflux of glycerol. In the proximal straight tubules of kidney, the encoded protein is localized to the apical membrane and prevents excretion of glycerol into urine. The encoded protein is present in spermatids, as well as in the testicular and epididymal spermatozoa suggesting an important role in late spermatogenesis. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related aquaporin gene on chromosome 9. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Dec 2015]

Gene Name: Aquaporin 7

Chromosome: CHR9: 33384947 -33402517

Locus: 9p13.3

B4GALT1 Gene Summary

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. [provided by RefSeq, Jul 2008]

Gene Name: Beta-1,4-galactosyltransferase 1

Chromosome: CHR9: 33110638 -33167356

Locus: 9p21.1

Gene Diseases

The B4GALT1 AQP7 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.