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B4GALT1-NFX1 Fusion FISH Probe

The B4GALT1-NFX1 Fusion FISH Probe is used to confirm a fusion of the B4GALT1 and NFX1 genes. The fusion of the B4GALT1 and NFX1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
B4GALT1-NFX1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
B4GALT1-NFX1-20-RERE 20 (40 μL) 200 μL
B4GALT1-NFX1-20-REOR 20 (40 μL) 200 μL
B4GALT1-NFX1-20-REGO 20 (40 μL) 200 μL
B4GALT1-NFX1-20-REGR 20 (40 μL) 200 μL
B4GALT1-NFX1-20-REAQ 20 (40 μL) 200 μL
B4GALT1-NFX1-20-ORRE 20 (40 μL) 200 μL
B4GALT1-NFX1-20-OROR 20 (40 μL) 200 μL
B4GALT1-NFX1-20-ORGO 20 (40 μL) 200 μL
B4GALT1-NFX1-20-ORAQ 20 (40 μL) 200 μL
B4GALT1-NFX1-20-GORE 20 (40 μL) 200 μL
B4GALT1-NFX1-20-GOOR 20 (40 μL) 200 μL
B4GALT1-NFX1-20-GOGO 20 (40 μL) 200 μL
B4GALT1-NFX1-20-GOGR 20 (40 μL) 200 μL
B4GALT1-NFX1-20-GOAQ 20 (40 μL) 200 μL
B4GALT1-NFX1-20-GRRE 20 (40 μL) 200 μL
B4GALT1-NFX1-20-GROR 20 (40 μL) 200 μL
B4GALT1-NFX1-20-GRGO 20 (40 μL) 200 μL
B4GALT1-NFX1-20-GRGR 20 (40 μL) 200 μL
B4GALT1-NFX1-20-GRAQ 20 (40 μL) 200 μL
B4GALT1-NFX1-20-AQRE 20 (40 μL) 200 μL
B4GALT1-NFX1-20-AQOR 20 (40 μL) 200 μL
B4GALT1-NFX1-20-AQGO 20 (40 μL) 200 μL
B4GALT1-NFX1-20-AQGR 20 (40 μL) 200 μL
B4GALT1-NFX1-20-AQAQ 20 (40 μL) 200 μL

B4GALT1 Gene Summary

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. [provided by RefSeq, Jul 2008]

Gene Name: Beta-1,4-galactosyltransferase 1

Chromosome: CHR9: 33110638 -33167356

Locus: 9p21.1

NFX1 Gene Summary

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]

Gene Name: Nuclear Transcription Factor, X-box Binding 1

Chromosome: CHR9: 33290417 -33371155

Locus: 9p13.3

Gene Diseases

The B4GALT1 NFX1 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.