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BAP1-PBRM1 Fusion FISH Probe

The BAP1-PBRM1 Fusion FISH Probe is used to confirm a fusion of the BAP1 and PBRM1 genes. The fusion of the BAP1 and PBRM1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
BAP1-PBRM1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
BAP1-PBRM1-20-RERE 20 (40 μL) 200 μL
BAP1-PBRM1-20-REOR 20 (40 μL) 200 μL
BAP1-PBRM1-20-REGO 20 (40 μL) 200 μL
BAP1-PBRM1-20-REGR 20 (40 μL) 200 μL
BAP1-PBRM1-20-REAQ 20 (40 μL) 200 μL
BAP1-PBRM1-20-ORRE 20 (40 μL) 200 μL
BAP1-PBRM1-20-OROR 20 (40 μL) 200 μL
BAP1-PBRM1-20-ORGO 20 (40 μL) 200 μL
BAP1-PBRM1-20-ORAQ 20 (40 μL) 200 μL
BAP1-PBRM1-20-GORE 20 (40 μL) 200 μL
BAP1-PBRM1-20-GOOR 20 (40 μL) 200 μL
BAP1-PBRM1-20-GOGO 20 (40 μL) 200 μL
BAP1-PBRM1-20-GOGR 20 (40 μL) 200 μL
BAP1-PBRM1-20-GOAQ 20 (40 μL) 200 μL
BAP1-PBRM1-20-GRRE 20 (40 μL) 200 μL
BAP1-PBRM1-20-GROR 20 (40 μL) 200 μL
BAP1-PBRM1-20-GRGO 20 (40 μL) 200 μL
BAP1-PBRM1-20-GRGR 20 (40 μL) 200 μL
BAP1-PBRM1-20-GRAQ 20 (40 μL) 200 μL
BAP1-PBRM1-20-AQRE 20 (40 μL) 200 μL
BAP1-PBRM1-20-AQOR 20 (40 μL) 200 μL
BAP1-PBRM1-20-AQGO 20 (40 μL) 200 μL
BAP1-PBRM1-20-AQGR 20 (40 μL) 200 μL
BAP1-PBRM1-20-AQAQ 20 (40 μL) 200 μL

BAP1 Gene Summary

This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]

Gene Name: BRCA1 Associated Protein 1

Chromosome: CHR3: 52435024 -52444009

Locus: 3p21.1

PBRM1 Gene Summary

This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]

Gene Name: Polybromo 1

Chromosome: CHR3: 52579367 -52719866

Locus: 3p21.1

Gene Diseases

The BAP1 PBRM1 Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.