BCAR3-DNTTIP2 Fusion FISH Probe
The BCAR3-DNTTIP2 Fusion FISH Probe is used to confirm a fusion of the BCAR3 and DNTTIP2 genes. The fusion of the BCAR3 and DNTTIP2 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BCAR3-DNTTIP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-RERE | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-REOR | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-REGO | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-REGR | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-REAQ | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-ORRE | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-OROR | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-ORGO | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-GORE | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-GOOR | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-GOGO | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-GOGR | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-GRRE | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-GROR | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-GRGO | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-GRGR | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-AQRE | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-AQOR | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-AQGO | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-AQGR | 20 (40 μL) | 200 μL |
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| BCAR3-DNTTIP2-20-AQAQ | 20 (40 μL) | 200 μL |
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BCAR3 Gene Summary
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Name: BCAR3, NSP Family Adaptor Protein
Chromosome: CHR1: 94027348 -94147385
Locus: 1p22.1
DNTTIP2 Gene Summary
This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease. [provided by RefSeq, Dec 2010]
Gene Name: Deoxynucleotidyltransferase Terminal Interacting Protein 2
Chromosome: CHR1: 94335013 -94344762
Locus: 1p22.1
Gene Diseases
The BCAR3 DNTTIP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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