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BCR-HIC2 Fusion FISH Probe

The BCR-HIC2 Fusion FISH Probe is used to confirm a fusion of the BCR and HIC2 genes. The fusion of the BCR and HIC2 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
BCR-HIC2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
BCR-HIC2-20-RERE 20 (40 μL) 200 μL
BCR-HIC2-20-REOR 20 (40 μL) 200 μL
BCR-HIC2-20-REGO 20 (40 μL) 200 μL
BCR-HIC2-20-REGR 20 (40 μL) 200 μL
BCR-HIC2-20-REAQ 20 (40 μL) 200 μL
BCR-HIC2-20-ORRE 20 (40 μL) 200 μL
BCR-HIC2-20-OROR 20 (40 μL) 200 μL
BCR-HIC2-20-ORGO 20 (40 μL) 200 μL
BCR-HIC2-20-ORAQ 20 (40 μL) 200 μL
BCR-HIC2-20-GORE 20 (40 μL) 200 μL
BCR-HIC2-20-GOOR 20 (40 μL) 200 μL
BCR-HIC2-20-GOGO 20 (40 μL) 200 μL
BCR-HIC2-20-GOGR 20 (40 μL) 200 μL
BCR-HIC2-20-GOAQ 20 (40 μL) 200 μL
BCR-HIC2-20-GRRE 20 (40 μL) 200 μL
BCR-HIC2-20-GROR 20 (40 μL) 200 μL
BCR-HIC2-20-GRGO 20 (40 μL) 200 μL
BCR-HIC2-20-GRGR 20 (40 μL) 200 μL
BCR-HIC2-20-GRAQ 20 (40 μL) 200 μL
BCR-HIC2-20-AQRE 20 (40 μL) 200 μL
BCR-HIC2-20-AQOR 20 (40 μL) 200 μL
BCR-HIC2-20-AQGO 20 (40 μL) 200 μL
BCR-HIC2-20-AQGR 20 (40 μL) 200 μL
BCR-HIC2-20-AQAQ 20 (40 μL) 200 μL

BCR Gene Summary

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Name: BCR, RhoGEF And GTPase Activating Protein

Chromosome: CHR22: 23522551 -23660224

Locus: 22q11.23

HIC2 Gene Summary

The HIC ZBTB Transcriptional Repressor 2 (HIC2) gene is located on chr22 :21771692-21805750 at 22q11.21.

Gene Name: HIC ZBTB Transcriptional Repressor 2

Chromosome: CHR22: 21771692 -21805750

Locus: 22q11.21

Gene Diseases

The BCR HIC2 Fusion has been associated with the following diseases:

Disease Name
Uterine Carcinosarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.