BIRC6-EML4 Fusion FISH Probe
The BIRC6-EML4 Fusion FISH Probe is used to confirm a fusion of the BIRC6 and EML4 genes. The fusion of the BIRC6 and EML4 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BIRC6-EML4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-RERE | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-REOR | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-REGO | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-REGR | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-REAQ | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-ORRE | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-OROR | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-ORGO | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-ORAQ | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-GORE | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-GOOR | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-GOGO | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-GOGR | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-GOAQ | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-GRRE | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-GROR | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-GRGO | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-GRGR | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-GRAQ | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-AQRE | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-AQOR | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-AQGO | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-AQGR | 20 (40 μL) | 200 μL |
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| BIRC6-EML4-20-AQAQ | 20 (40 μL) | 200 μL |
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EML4 Gene Summary
This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]
Gene Name: Echinoderm Microtubule Associated Protein Like 4
Chromosome: CHR2: 42396489 -42559688
Locus: 2p21
BIRC6 Gene Summary
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
Gene Name: Baculoviral IAP Repeat Containing 6
Chromosome: CHR2: 32582095 -32843965
Locus: 2p22.3
Gene Diseases
The BIRC6 EML4 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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