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BMPR1B-MCC Fusion FISH Probe

The BMPR1B-MCC Fusion FISH Probe is used to confirm a fusion of the BMPR1B and MCC genes. The fusion of the BMPR1B and MCC genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
BMPR1B-MCC-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
BMPR1B-MCC-20-RERE 20 (40 μL) 200 μL
BMPR1B-MCC-20-REOR 20 (40 μL) 200 μL
BMPR1B-MCC-20-REGO 20 (40 μL) 200 μL
BMPR1B-MCC-20-REGR 20 (40 μL) 200 μL
BMPR1B-MCC-20-REAQ 20 (40 μL) 200 μL
BMPR1B-MCC-20-ORRE 20 (40 μL) 200 μL
BMPR1B-MCC-20-OROR 20 (40 μL) 200 μL
BMPR1B-MCC-20-ORGO 20 (40 μL) 200 μL
BMPR1B-MCC-20-ORAQ 20 (40 μL) 200 μL
BMPR1B-MCC-20-GORE 20 (40 μL) 200 μL
BMPR1B-MCC-20-GOOR 20 (40 μL) 200 μL
BMPR1B-MCC-20-GOGO 20 (40 μL) 200 μL
BMPR1B-MCC-20-GOGR 20 (40 μL) 200 μL
BMPR1B-MCC-20-GOAQ 20 (40 μL) 200 μL
BMPR1B-MCC-20-GRRE 20 (40 μL) 200 μL
BMPR1B-MCC-20-GROR 20 (40 μL) 200 μL
BMPR1B-MCC-20-GRGO 20 (40 μL) 200 μL
BMPR1B-MCC-20-GRGR 20 (40 μL) 200 μL
BMPR1B-MCC-20-GRAQ 20 (40 μL) 200 μL
BMPR1B-MCC-20-AQRE 20 (40 μL) 200 μL
BMPR1B-MCC-20-AQOR 20 (40 μL) 200 μL
BMPR1B-MCC-20-AQGO 20 (40 μL) 200 μL
BMPR1B-MCC-20-AQGR 20 (40 μL) 200 μL
BMPR1B-MCC-20-AQAQ 20 (40 μL) 200 μL

BMPR1B Gene Summary

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Gene Name: Bone Morphogenetic Protein Receptor Type 1B

Chromosome: CHR4: 95679127 -96079601

Locus: 4q22.3

MCC Gene Summary

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Name: Mutated In Colorectal Cancers

Chromosome: CHR5: 112357795 -112824527

Locus: 5q22.2

Gene Diseases

The BMPR1B MCC Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.