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BRAF-AGK Fusion FISH Probe

The BRAF-AGK Fusion FISH Probe is used to confirm a fusion of the BRAF and AGK genes. The fusion of the BRAF and AGK genes has been associated with Skin Cutaneous Melanoma, and Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
BRAF-AGK-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
BRAF-AGK-20-RERE 20 (40 μL) 200 μL
BRAF-AGK-20-REOR 20 (40 μL) 200 μL
BRAF-AGK-20-REGO 20 (40 μL) 200 μL
BRAF-AGK-20-REGR 20 (40 μL) 200 μL
BRAF-AGK-20-REAQ 20 (40 μL) 200 μL
BRAF-AGK-20-ORRE 20 (40 μL) 200 μL
BRAF-AGK-20-OROR 20 (40 μL) 200 μL
BRAF-AGK-20-ORGO 20 (40 μL) 200 μL
BRAF-AGK-20-ORAQ 20 (40 μL) 200 μL
BRAF-AGK-20-GORE 20 (40 μL) 200 μL
BRAF-AGK-20-GOOR 20 (40 μL) 200 μL
BRAF-AGK-20-GOGO 20 (40 μL) 200 μL
BRAF-AGK-20-GOGR 20 (40 μL) 200 μL
BRAF-AGK-20-GOAQ 20 (40 μL) 200 μL
BRAF-AGK-20-GRRE 20 (40 μL) 200 μL
BRAF-AGK-20-GROR 20 (40 μL) 200 μL
BRAF-AGK-20-GRGO 20 (40 μL) 200 μL
BRAF-AGK-20-GRGR 20 (40 μL) 200 μL
BRAF-AGK-20-GRAQ 20 (40 μL) 200 μL
BRAF-AGK-20-AQRE 20 (40 μL) 200 μL
BRAF-AGK-20-AQOR 20 (40 μL) 200 μL
BRAF-AGK-20-AQGO 20 (40 μL) 200 μL
BRAF-AGK-20-AQGR 20 (40 μL) 200 μL
BRAF-AGK-20-AQAQ 20 (40 μL) 200 μL

BRAF Gene Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]

Gene Name: B-Raf Proto-oncogene, Serine/threonine Kinase

Chromosome: CHR7: 140433812 -140624564

Locus: 7q34

AGK Gene Summary

The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. [provided by RefSeq, Feb 2012]

Gene Name: Acylglycerol Kinase

Chromosome: CHR7: 141251077 -141354209

Locus: 7q34

Gene Diseases

The BRAF AGK Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma
Thyroid Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.