BRAF-CIITA Fusion FISH Probe
The BRAF-CIITA Fusion FISH Probe is used to confirm a fusion of the BRAF and CIITA genes. The fusion of the BRAF and CIITA genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BRAF-CIITA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-RERE | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-REOR | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-REGO | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-REGR | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-REAQ | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-ORRE | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-OROR | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-ORGO | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-ORAQ | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-GORE | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-GOOR | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-GOGO | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-GOGR | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-GOAQ | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-GRRE | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-GROR | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-GRGO | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-GRGR | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-GRAQ | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-AQRE | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-AQOR | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-AQGO | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-AQGR | 20 (40 μL) | 200 μL |
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| BRAF-CIITA-20-AQAQ | 20 (40 μL) | 200 μL |
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BRAF Gene Summary
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Gene Name: B-Raf Proto-oncogene, Serine/threonine Kinase
Chromosome: CHR7: 140433812 -140624564
Locus: 7q34
CIITA Gene Summary
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Name: Class II Major Histocompatibility Complex Transactivator
Chromosome: CHR16: 10971054 -11018840
Locus: 16p13.13
Gene Diseases
The BRAF CIITA Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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