BRAF-MRPS33 Fusion FISH Probe
The BRAF-MRPS33 Fusion FISH Probe is used to confirm a fusion of the BRAF and MRPS33 genes. The fusion of the BRAF and MRPS33 genes has been associated with Bladder Urothelial Carcinoma, and Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BRAF-MRPS33-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-RERE | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-REOR | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-REGO | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-REGR | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-REAQ | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-ORRE | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-OROR | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-ORGO | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-ORAQ | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-GORE | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-GOOR | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-GOGO | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-GOGR | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-GOAQ | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-GRRE | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-GROR | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-GRGO | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-GRGR | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-GRAQ | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-AQRE | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-AQOR | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-AQGO | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-AQGR | 20 (40 μL) | 200 μL |
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| BRAF-MRPS33-20-AQAQ | 20 (40 μL) | 200 μL |
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BRAF Gene Summary
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Gene Name: B-Raf Proto-oncogene, Serine/threonine Kinase
Chromosome: CHR7: 140433812 -140624564
Locus: 7q34
MRPS33 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and C. elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein S33
Chromosome: CHR7: 140705960 -140714781
Locus: 7q34
Gene Diseases
The BRAF MRPS33 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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