BRAP-KLRB1 Fusion FISH Probe
The BRAP-KLRB1 Fusion FISH Probe is used to confirm a fusion of the BRAP and KLRB1 genes. The fusion of the BRAP and KLRB1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BRAP-KLRB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-RERE | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-REOR | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-REGO | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-REGR | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-REAQ | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-ORRE | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-OROR | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-ORGO | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-GORE | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-GOOR | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-GOGO | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-GOGR | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-GRRE | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-GROR | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-GRGO | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-GRGR | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-AQRE | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-AQOR | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-AQGO | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-AQGR | 20 (40 μL) | 200 μL |
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| BRAP-KLRB1-20-AQAQ | 20 (40 μL) | 200 μL |
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KLRB1 Gene Summary
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
Gene Name: Killer Cell Lectin Like Receptor B1
Chromosome: CHR12: 9747869 -9760497
Locus: 12p13.31
BRAP Gene Summary
The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]
Gene Name: BRCA1 Associated Protein
Chromosome: CHR12: 112079949 -112123790
Locus: 12q24.12
Gene Diseases
The BRAP KLRB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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