BRD1-MLC1 Fusion FISH Probe
The BRD1-MLC1 Fusion FISH Probe is used to confirm a fusion of the BRD1 and MLC1 genes. The fusion of the BRD1 and MLC1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BRD1-MLC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-RERE | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-REOR | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-REGO | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-REGR | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-REAQ | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-ORRE | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-OROR | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-ORGO | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-GORE | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-GOOR | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-GOGO | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-GOGR | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-GRRE | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-GROR | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-GRGO | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-GRGR | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-AQRE | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-AQOR | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-AQGO | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-AQGR | 20 (40 μL) | 200 μL |
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| BRD1-MLC1-20-AQAQ | 20 (40 μL) | 200 μL |
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MLC1 Gene Summary
The function of this gene product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in this gene have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Megalencephalic Leukoencephalopathy With Subcortical Cysts 1
Chromosome: CHR22: 50497819 -50524358
Locus: 22q13.33
BRD1 Gene Summary
This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]
Gene Name: Bromodomain Containing 1
Chromosome: CHR22: 50166936 -50218452
Locus: 22q13.33
Gene Diseases
The BRD1 MLC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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