BRD4-AKAP8L Fusion FISH Probe
The BRD4-AKAP8L Fusion FISH Probe is used to confirm a fusion of the BRD4 and AKAP8L genes. The fusion of the BRD4 and AKAP8L genes has been associated with Liver Hepatocellular Carcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BRD4-AKAP8L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-RERE | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-REOR | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-REGO | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-REGR | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-REAQ | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-ORRE | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-OROR | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-ORGO | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-ORAQ | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-GORE | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-GOOR | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-GOGO | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-GOGR | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-GOAQ | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-GRRE | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-GROR | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-GRGO | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-GRGR | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-GRAQ | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-AQRE | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-AQOR | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-AQGO | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-AQGR | 20 (40 μL) | 200 μL |
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| BRD4-AKAP8L-20-AQAQ | 20 (40 μL) | 200 μL |
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BRD4 Gene Summary
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Gene Name: Bromodomain Containing 4
Chromosome: CHR19: 15348300 -15391262
Locus: 19p13.12
AKAP8L Gene Summary
The A-kinase Anchoring Protein 8 Like (AKAP8L) gene is located on chr19 :15490858-15529833 at 19p13.12.
Gene Name: A-kinase Anchoring Protein 8 Like
Chromosome: CHR19: 15490858 -15529833
Locus: 19p13.12
Gene Diseases
The BRD4 AKAP8L Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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