BRWD1-SMC1A Fusion FISH Probe
The BRWD1-SMC1A Fusion FISH Probe is used to confirm a fusion of the BRWD1 and SMC1A genes. The fusion of the BRWD1 and SMC1A genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BRWD1-SMC1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-RERE | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-REOR | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-REGO | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-REGR | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-REAQ | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-ORRE | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-OROR | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-ORGO | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-GORE | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-GOOR | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-GOGO | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-GOGR | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-GRRE | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-GROR | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-GRGO | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-GRGR | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-AQRE | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-AQOR | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-AQGO | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-AQGR | 20 (40 μL) | 200 μL |
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| BRWD1-SMC1A-20-AQAQ | 20 (40 μL) | 200 μL |
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SMC1A Gene Summary
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Gene Name: Structural Maintenance Of Chromosomes 1A
Chromosome: CHRX: 53401069 -53449618
Locus: Xp11.22
BRWD1 Gene Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
Gene Name: Bromodomain And WD Repeat Domain Containing 1
Chromosome: CHR21: 40557403 -40685712
Locus: 21q22.2
Gene Diseases
The BRWD1 SMC1A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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