BRWD1-WRB Fusion FISH Probe
The BRWD1-WRB Fusion FISH Probe is used to confirm a fusion of the BRWD1 and WRB genes. The fusion of the BRWD1 and WRB genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BRWD1-WRB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-RERE | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-REOR | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-REGO | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-REGR | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-REAQ | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-ORRE | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-OROR | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-ORGO | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-ORAQ | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-GORE | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-GOOR | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-GOGO | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-GOGR | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-GOAQ | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-GRRE | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-GROR | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-GRGO | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-GRGR | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-GRAQ | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-AQRE | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-AQOR | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-AQGO | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-AQGR | 20 (40 μL) | 200 μL |
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| BRWD1-WRB-20-AQAQ | 20 (40 μL) | 200 μL |
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WRB Gene Summary
This gene is located in the candidate region for congenital heart disease (CHD) in Down syndrome (DS). It encodes a basic protein that functions as a receptor that promotes insertion of tail-anchored proteins in the endoplasmic reticulum membrane. This gene is located at a maternally-methylated differentially methylated region (DMR); however, its transcription may be biallelic, not imprinted. Alternative splicing results in different transcript variants. A pseudogene has been defined on chromosome 4. [provided by RefSeq, Apr 2017]
Gene Name: Tryptophan Rich Basic Protein
Chromosome: CHR21: 40752212 -40769815
Locus: 21q22.2
BRWD1 Gene Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
Gene Name: Bromodomain And WD Repeat Domain Containing 1
Chromosome: CHR21: 40557403 -40685712
Locus: 21q22.2
Gene Diseases
The BRWD1 WRB Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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