BTBD1-MRPL46 Fusion FISH Probe
The BTBD1-MRPL46 Fusion FISH Probe is used to confirm a fusion of the BTBD1 and MRPL46 genes. The fusion of the BTBD1 and MRPL46 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BTBD1-MRPL46-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-RERE | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-REOR | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-REGO | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-REGR | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-REAQ | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-ORRE | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-OROR | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-ORGO | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-ORAQ | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-GORE | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-GOOR | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-GOGO | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-GOGR | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-GOAQ | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-GRRE | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-GROR | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-GRGO | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-GRGR | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-GRAQ | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-AQRE | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-AQOR | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-AQGO | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-AQGR | 20 (40 μL) | 200 μL |
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| BTBD1-MRPL46-20-AQAQ | 20 (40 μL) | 200 μL |
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MRPL46 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein L46
Chromosome: CHR15: 89002708 -89010633
Locus: 15q25.3
BTBD1 Gene Summary
The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: BTB Domain Containing 1
Chromosome: CHR15: 83685180 -83736106
Locus: 15q25.2
Gene Diseases
The BTBD1 MRPL46 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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