BTRC-CDH23 Fusion FISH Probe
The BTRC-CDH23 Fusion FISH Probe is used to confirm a fusion of the BTRC and CDH23 genes. The fusion of the BTRC and CDH23 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BTRC-CDH23-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-RERE | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-REOR | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-REGO | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-REGR | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-REAQ | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-ORRE | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-OROR | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-ORGO | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-ORAQ | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-GORE | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-GOOR | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-GOGO | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-GOGR | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-GOAQ | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-GRRE | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-GROR | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-GRGO | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-GRGR | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-GRAQ | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-AQRE | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-AQOR | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-AQGO | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-AQGR | 20 (40 μL) | 200 μL |
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| BTRC-CDH23-20-AQAQ | 20 (40 μL) | 200 μL |
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BTRC Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
Gene Name: Beta-transducin Repeat Containing E3 Ubiquitin Protein Ligase
Chromosome: CHR10: 103113824 -103317070
Locus: 10q24.32
CDH23 Gene Summary
This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, May 2013]
Gene Name: Cadherin Related 23
Chromosome: CHR10: 73156690 -73575704
Locus: 10q22.1
Gene Diseases
The BTRC CDH23 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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