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BTRC-HIF1AN Fusion FISH Probe

The BTRC-HIF1AN Fusion FISH Probe is used to confirm a fusion of the BTRC and HIF1AN genes. The fusion of the BTRC and HIF1AN genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
BTRC-HIF1AN-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
BTRC-HIF1AN-20-RERE 20 (40 μL) 200 μL
BTRC-HIF1AN-20-REOR 20 (40 μL) 200 μL
BTRC-HIF1AN-20-REGO 20 (40 μL) 200 μL
BTRC-HIF1AN-20-REGR 20 (40 μL) 200 μL
BTRC-HIF1AN-20-REAQ 20 (40 μL) 200 μL
BTRC-HIF1AN-20-ORRE 20 (40 μL) 200 μL
BTRC-HIF1AN-20-OROR 20 (40 μL) 200 μL
BTRC-HIF1AN-20-ORGO 20 (40 μL) 200 μL
BTRC-HIF1AN-20-ORAQ 20 (40 μL) 200 μL
BTRC-HIF1AN-20-GORE 20 (40 μL) 200 μL
BTRC-HIF1AN-20-GOOR 20 (40 μL) 200 μL
BTRC-HIF1AN-20-GOGO 20 (40 μL) 200 μL
BTRC-HIF1AN-20-GOGR 20 (40 μL) 200 μL
BTRC-HIF1AN-20-GOAQ 20 (40 μL) 200 μL
BTRC-HIF1AN-20-GRRE 20 (40 μL) 200 μL
BTRC-HIF1AN-20-GROR 20 (40 μL) 200 μL
BTRC-HIF1AN-20-GRGO 20 (40 μL) 200 μL
BTRC-HIF1AN-20-GRGR 20 (40 μL) 200 μL
BTRC-HIF1AN-20-GRAQ 20 (40 μL) 200 μL
BTRC-HIF1AN-20-AQRE 20 (40 μL) 200 μL
BTRC-HIF1AN-20-AQOR 20 (40 μL) 200 μL
BTRC-HIF1AN-20-AQGO 20 (40 μL) 200 μL
BTRC-HIF1AN-20-AQGR 20 (40 μL) 200 μL
BTRC-HIF1AN-20-AQAQ 20 (40 μL) 200 μL

BTRC Gene Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]

Gene Name: Beta-transducin Repeat Containing E3 Ubiquitin Protein Ligase

Chromosome: CHR10: 103113824 -103317070

Locus: 10q24.32

HIF1AN Gene Summary

The Hypoxia Inducible Factor 1 Alpha Subunit Inhibitor (HIF1AN) gene is located on chr10 :102295640-102313681 at 10q24.31.

Gene Name: Hypoxia Inducible Factor 1 Alpha Subunit Inhibitor

Chromosome: CHR10: 102295640 -102313681

Locus: 10q24.31

Gene Diseases

The BTRC HIF1AN Fusion has been associated with the following diseases:

Disease Name
Kidney Renal Clear Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.