C12ORF65-EIF4EBP1 Fusion FISH Probe
The C12ORF65-EIF4EBP1 Fusion FISH Probe is used to confirm a fusion of the C12ORF65 and EIF4EBP1 genes. The fusion of the C12ORF65 and EIF4EBP1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| C12ORF65-EIF4EBP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-RERE | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-REOR | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-REGO | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-REGR | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-REAQ | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-ORRE | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-OROR | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-ORGO | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-GORE | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-GOOR | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-GOGO | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-GOGR | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-GRRE | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-GROR | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-GRGO | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-GRGR | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-AQRE | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-AQOR | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-AQGO | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-AQGR | 20 (40 μL) | 200 μL |
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| C12ORF65-EIF4EBP1-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF4EBP1 Gene Summary
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
Gene Name: Eukaryotic Translation Initiation Factor 4E Binding Protein 1
Chromosome: CHR8: 37888019 -37917883
Locus: 8p11.23
C12orf65 Gene Summary
This nuclear gene encodes a mitochondrial matrix protein that appears to contribute to peptide chain termination in the mitochondrial translation machinery. Two different 1 bp deletions (resulting in the same premature stop codon)result in decreased mitochondrial translation, decreased levels of oxidative phosphorylation complexes and encepthalomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Gene Name: Chromosome 12 Open Reading Frame 65
Chromosome: CHR12: 123717843 -123742506
Locus: 12q24.31
Gene Diseases
The C12ORF65 EIF4EBP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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