C18ORF45-NPC1 Fusion FISH Probe
The C18ORF45-NPC1 Fusion FISH Probe is used to confirm a fusion of the C18ORF45 and NPC1 genes. The fusion of the C18ORF45 and NPC1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| C18ORF45-NPC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-RERE | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-REOR | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-REGO | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-REGR | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-REAQ | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-ORRE | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-OROR | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-ORGO | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-GORE | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-GOOR | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-GOGO | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-GOGR | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-GRRE | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-GROR | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-GRGO | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-GRGR | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-AQRE | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-AQOR | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-AQGO | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-AQGR | 20 (40 μL) | 200 μL |
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| C18ORF45-NPC1-20-AQAQ | 20 (40 μL) | 200 μL |
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NPC1 Gene Summary
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009]
Gene Name: NPC Intracellular Cholesterol Transporter 1
Chromosome: CHR18: 21111462 -21166581
Locus: 18q11.2
Gene Diseases
The C18ORF45 NPC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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