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CA3-MYBL1 Fusion FISH Probe

The CA3-MYBL1 Fusion FISH Probe is used to confirm a fusion of the CA3 and MYBL1 genes. The fusion of the CA3 and MYBL1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
CA3-MYBL1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CA3-MYBL1-20-RERE 20 (40 μL) 200 μL
CA3-MYBL1-20-REOR 20 (40 μL) 200 μL
CA3-MYBL1-20-REGO 20 (40 μL) 200 μL
CA3-MYBL1-20-REGR 20 (40 μL) 200 μL
CA3-MYBL1-20-REAQ 20 (40 μL) 200 μL
CA3-MYBL1-20-ORRE 20 (40 μL) 200 μL
CA3-MYBL1-20-OROR 20 (40 μL) 200 μL
CA3-MYBL1-20-ORGO 20 (40 μL) 200 μL
CA3-MYBL1-20-ORAQ 20 (40 μL) 200 μL
CA3-MYBL1-20-GORE 20 (40 μL) 200 μL
CA3-MYBL1-20-GOOR 20 (40 μL) 200 μL
CA3-MYBL1-20-GOGO 20 (40 μL) 200 μL
CA3-MYBL1-20-GOGR 20 (40 μL) 200 μL
CA3-MYBL1-20-GOAQ 20 (40 μL) 200 μL
CA3-MYBL1-20-GRRE 20 (40 μL) 200 μL
CA3-MYBL1-20-GROR 20 (40 μL) 200 μL
CA3-MYBL1-20-GRGO 20 (40 μL) 200 μL
CA3-MYBL1-20-GRGR 20 (40 μL) 200 μL
CA3-MYBL1-20-GRAQ 20 (40 μL) 200 μL
CA3-MYBL1-20-AQRE 20 (40 μL) 200 μL
CA3-MYBL1-20-AQOR 20 (40 μL) 200 μL
CA3-MYBL1-20-AQGO 20 (40 μL) 200 μL
CA3-MYBL1-20-AQGR 20 (40 μL) 200 μL
CA3-MYBL1-20-AQAQ 20 (40 μL) 200 μL

CA3 Gene Summary

Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008]

Gene Name: Carbonic Anhydrase 3

Chromosome: CHR8: 86351055 -86361267

Locus: 8q21.2

MYBL1 Gene Summary

The MYB Proto-oncogene Like 1 (MYBL1) gene is located on chr8 :67474409-67525480 at 8q13.1.

Gene Name: MYB Proto-oncogene Like 1

Chromosome: CHR8: 67474409 -67525480

Locus: 8q13.1

Gene Diseases

The CA3 MYBL1 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Genetic rearrangements, hotspot mutations, and microRNA expression in the progression of metastatic adenoid cystic carcinoma of the salivary gland

Adenoid cystic carcinoma (ACC) is a common salivary gland malignancy. The malignancy is associated with gene fusions between MYB, MYBL1, and NFIB. FISH analysis was used to evaluate any rearrangements in these genes with the use of our break apart probes. It was found through FISH that MYB aberrations were preserved between primary tumors and metastases. Additionally, MYB and NFIB aberrations are preserved in ACC metastatic lesions.
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MicroRNA dysregulation in adenoid cystic carcinoma of the salivary gland in relation to prognosis and gene fusion status: a cohort study

Adenoid cystic carcinoma (ACC) is a frequent malignancy of the salivary gland that is challenging due to an unpredictable clinical course. In hopes of improving this predictability, the association of microRNA with prognostic value in ACC is under study. Along with microRNA tests, FISH analysis was performed with various break apart probes, including our MYLB1 and NFIB probes, to look for any fusion or rearrangement. It was found that several microRNAs were associated with the outcome of ACC and that the most unifying feature of ACC is still involvement of the MYB gene.
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Molecular features of adenoid cystic carcinoma with an emphasis on microRNA expression

Adenoid cystic carcinoma (ACC) is a subtype of salivary gland tumor that can have a poor prognosis. ACC can also be present in lacrimal glands and the breasts with the tumors appearing to be seemingly identical to one another. The phenotypes, genetics, and microRNA expression of ACC in the salivary glands, lacrimal glands, and breasts was characterized in order to better understand the differences between them. Among other characterization tools, FISH analysis was performed with several break apart probes, including our MYBL1 and NFIB probes. The results seemed to indicate that microRNA has value in distinguishing between the tumors.
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