CABIN1-POLR2F Fusion FISH Probe
The CABIN1-POLR2F Fusion FISH Probe is used to confirm a fusion of the CABIN1 and POLR2F genes. The fusion of the CABIN1 and POLR2F genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CABIN1-POLR2F-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-RERE | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-REOR | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-REGO | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-REGR | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-REAQ | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-ORRE | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-OROR | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-ORGO | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-ORAQ | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-GORE | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-GOOR | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-GOGO | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-GOGR | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-GOAQ | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-GRRE | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-GROR | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-GRGO | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-GRGR | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-GRAQ | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-AQRE | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-AQOR | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-AQGO | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-AQGR | 20 (40 μL) | 200 μL |
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| CABIN1-POLR2F-20-AQAQ | 20 (40 μL) | 200 μL |
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POLR2F Gene Summary
This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: RNA Polymerase II Subunit F
Chromosome: CHR22: 38349673 -38365319
Locus: 22q13.1
CABIN1 Gene Summary
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]
Gene Name: Calcineurin Binding Protein 1
Chromosome: CHR22: 24407764 -24574596
Locus: 22q11.23
Gene Diseases
The CABIN1 POLR2F Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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