CABIN1-SMARCB1 Fusion FISH Probe
The CABIN1-SMARCB1 Fusion FISH Probe is used to confirm a fusion of the CABIN1 and SMARCB1 genes. The fusion of the CABIN1 and SMARCB1 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CABIN1-SMARCB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-RERE | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-REOR | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-REGO | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-REGR | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-REAQ | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-ORRE | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-OROR | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-ORGO | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-GORE | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-GOOR | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-GOGO | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-GOGR | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-GRRE | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-GROR | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-GRGO | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-GRGR | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-AQRE | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-AQOR | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-AQGO | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-AQGR | 20 (40 μL) | 200 μL |
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| CABIN1-SMARCB1-20-AQAQ | 20 (40 μL) | 200 μL |
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SMARCB1 Gene Summary
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Gene Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1
Chromosome: CHR22: 24129149 -24176705
Locus: 22q11
CABIN1 Gene Summary
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]
Gene Name: Calcineurin Binding Protein 1
Chromosome: CHR22: 24407764 -24574596
Locus: 22q11.23
Gene Diseases
The CABIN1 SMARCB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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