CACNA1C-WNT5B Fusion FISH Probe
The CACNA1C-WNT5B Fusion FISH Probe is used to confirm a fusion of the CACNA1C and WNT5B genes. The fusion of the CACNA1C and WNT5B genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CACNA1C-WNT5B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-RERE | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-REOR | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-REGO | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-REGR | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-REAQ | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-ORRE | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-OROR | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-ORGO | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-ORAQ | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-GORE | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-GOOR | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-GOGO | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-GOGR | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-GOAQ | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-GRRE | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-GROR | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-GRGO | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-GRGR | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-GRAQ | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-AQRE | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-AQOR | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-AQGO | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-AQGR | 20 (40 μL) | 200 μL |
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| CACNA1C-WNT5B-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNA1C Gene Summary
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
Gene Name: Calcium Voltage-gated Channel Subunit Alpha1 C
Chromosome: CHR12: 2162415 -2807115
Locus: 12p13.33
WNT5B Gene Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Gene Name: Wnt Family Member 5B
Chromosome: CHR12: 1726221 -1756377
Locus: 12p13.33
Gene Diseases
The CACNA1C WNT5B Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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