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CACNA1D-GNL3 Fusion FISH Probe

The CACNA1D-GNL3 Fusion FISH Probe is used to confirm a fusion of the CACNA1D and GNL3 genes. The fusion of the CACNA1D and GNL3 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CACNA1D-GNL3-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CACNA1D-GNL3-20-RERE 20 (40 μL) 200 μL
CACNA1D-GNL3-20-REOR 20 (40 μL) 200 μL
CACNA1D-GNL3-20-REGO 20 (40 μL) 200 μL
CACNA1D-GNL3-20-REGR 20 (40 μL) 200 μL
CACNA1D-GNL3-20-REAQ 20 (40 μL) 200 μL
CACNA1D-GNL3-20-ORRE 20 (40 μL) 200 μL
CACNA1D-GNL3-20-OROR 20 (40 μL) 200 μL
CACNA1D-GNL3-20-ORGO 20 (40 μL) 200 μL
CACNA1D-GNL3-20-ORAQ 20 (40 μL) 200 μL
CACNA1D-GNL3-20-GORE 20 (40 μL) 200 μL
CACNA1D-GNL3-20-GOOR 20 (40 μL) 200 μL
CACNA1D-GNL3-20-GOGO 20 (40 μL) 200 μL
CACNA1D-GNL3-20-GOGR 20 (40 μL) 200 μL
CACNA1D-GNL3-20-GOAQ 20 (40 μL) 200 μL
CACNA1D-GNL3-20-GRRE 20 (40 μL) 200 μL
CACNA1D-GNL3-20-GROR 20 (40 μL) 200 μL
CACNA1D-GNL3-20-GRGO 20 (40 μL) 200 μL
CACNA1D-GNL3-20-GRGR 20 (40 μL) 200 μL
CACNA1D-GNL3-20-GRAQ 20 (40 μL) 200 μL
CACNA1D-GNL3-20-AQRE 20 (40 μL) 200 μL
CACNA1D-GNL3-20-AQOR 20 (40 μL) 200 μL
CACNA1D-GNL3-20-AQGO 20 (40 μL) 200 μL
CACNA1D-GNL3-20-AQGR 20 (40 μL) 200 μL
CACNA1D-GNL3-20-AQAQ 20 (40 μL) 200 μL

CACNA1D Gene Summary

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Gene Name: Calcium Voltage-gated Channel Subunit Alpha1 D

Chromosome: CHR3: 53529030 -53846492

Locus: 3p21.1

GNL3 Gene Summary

The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Gene Name: G Protein Nucleolar 3

Chromosome: CHR3: 52719935 -52728510

Locus: 3p21.1

Gene Diseases

The CACNA1D GNL3 Fusion has been associated with the following diseases:

Disease Name
Esophageal Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.